Management and perceptions of anemia and iron deficiency prior to cardiac surgery

Authors

DOI:

https://doi.org/10.47487/apcyccv.v7i1.598

Keywords:

Anemia, Iron Deficiencies, Cardiac Surgical Procedures, Perioperative Care, Surveys And Questionnaires

Abstract

Introduction. Anaemia and iron deficiency (ID) are common in patients with cardiovascular disease and are associated with increased morbidity and mortality in cardiac surgery. However, no data are available on how this issue is addressed in IberoAmerica. We therefore sought, under the auspices of the Inter-American Society of Cardiology, to explore the knowledge, attitudes, and practices of Latin American physicians involved in the perioperative care of patients undergoing cardiac surgery. Materials and methods. We conducted a cross-sectional study using an anonymous electronic survey distributed between January and August, 2025, through snowball sampling. Physicians engaged in clinical practice involving the care of patients prior to cardiac surgery were eligible for inclusion. Results. A total of 881 physicians from 23 countries responded. Although 83.7% reported routinely screening for anaemia, only 43.7% indicated that they assessed iron deficiency. Institutional protocols addressing this topic were reported by 18.2% of respondents. Marked heterogeneity was observed in therapeutic management: only 11.8% reported administering intravenous iron when anaemia or ID was diagnosed. While 46.9% of participants stated that they had routine access to intravenous iron, only 26.6% of these reported prescribing this intervention for patients in the preoperative cardiac surgery setting within the 6 months preceding the survey. Furthermore, 54.8% of respondents had not received specific training and felt only moderately prepared to manage these conditions. Conclusions. Our findings suggest substantial gaps between the available evidence and clinical practice in the preoperative management of anaemia and iron deficiency, underscoring the need for institutional protocols and enhanced specialised medical education.

Downloads

Download data is not yet available.

References

Auerbach M, DeLoughery TG, Tirnauer JS. Iron Deficiency in Adults: A Review. JAMA. 2025;333(20):1813-23. doi: 10.1001/ jama.2025.0452.

Savarese G, von Haehling S, Butler J, Cleland JGF, Ponikowski P, Anker SD. Iron deficiency and cardiovascular disease. Eur Heart J. 2023;44(1):14-27. doi: 10.1093/eurheartj/ehac569.

Sawicki KT, De Jesus A, Ardehali H. Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets. Circ Res. 2023;132(3):379-96. doi: 10.1161/ CIRCRESAHA.122.321667.

Writing Committee M, Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, et al. 2024 AHA/ACC/ACS/ ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024;84(19):1869-969. doi: 10.1016/j.jacc.2024.06.013.

Litton E, Shah A. Iron Deficiency and Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019;33(8):2151-2. doi: 10.1053/j. jvca.2019.03.050.

World Health Organization (WHO). The urgent need to implement patient blood management: Policy brief. Geneva: WHO; 2024.

Loncar G, Obradovic D, Thiele H, von Haehling S, Lainscak M. Iron deficiency in heart failure. ESC Heart Fail. 2021;8(4):2368-79. doi: 10.1002/ehf2.13265.

Ad N, Holmes SD, Patel J, Shuman DJ, Massimiano PS, Choi E, et al. The impact of a multidisciplinary blood conservation protocol on patient outcomes and cost after cardiac surgery. J Thorac Cardiovasc Surg. 2017;153(3):597-605 e1. doi: 10.1016/j. jtcvs.2016.10.083.

Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet. 2019;393(10187):2201-12. doi: 10.1016/ S0140-6736(18)32555-8.

Lau M, Low CJW, Ling RR, Liu NSH, Tan CS, Ti LK, et al. Preoperative anemia and anemia treatment in cardiac surgery: a systematic review and meta-analysis. Can J Anaesth. 2024;71(1):127-42. doi: 10.1007/s12630-023-02620-1.

Corsi F, Pasquini A, Guerrera M, Bevilacqua F, Taccheri T, Antoniucci ME, et al. Single shot of intravenous iron in cardiac surgery: The ICARUS study. J Clin Anesth. 2023;84:111009. doi: 10.1016/j. jclinane.2022.111009.

Sharma A, Minh Duc NT, Luu Lam Thang T, Nam NH, Ng SJ, Abbas KS, et al. A Consensus-Based Checklist for Reporting of Survey Studies (CROSS). J Gen Intern Med. 2021;36(10):3179-87. doi: 10.1007/s11606-021-06737-1.

Moher D, Collins G, Hoffmann T, Glasziou P, Ravaud P, Bian ZX. Reporting on data sharing: executive position of the EQUATOR Network. BMJ. 2024;386:e079694. doi: 10.1136/bmj-2024- 079694.

Rossler J, Schoenrath F, Seifert B, Kaserer A, Spahn GH, Falk V, et al. Iron deficiency is associated with higher mortality in patients undergoing cardiac surgery: a prospective study. Br J Anaesth. 2020;124(1):25-34. doi: 10.1016/j.bja.2019.09.016.

Imamura T. Association between iron deficiency and clinical outcomes following cardiac surgery. J Card Surg. 2021;36(6):2182. doi: 10.1111/jocs.15453.

Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, et al. Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019;33(8):2141-50. doi: 10.1053/j.jvca.2019.02.006

Meybohm P, Schmitt E, Choorapoikayil S, Hof L, Old O, Muller MM, et al. German Patient Blood Management Network: effectiveness and safety analysis in 1.2 million patients. Br J Anaesth. 2023;131(3):472-81. doi: 10.1016/j.bja.2023.05.006.

Padmanabhan H, Siau K, Curtis J, Ng A, Menon S, Luckraz H, et al. Preoperative Anemia and Outcomes in Cardiovascular Surgery: Systematic Review and Meta-Analysis. Ann Thorac Surg. 2019;108(6):1840-8. doi: 10.1016/j.athoracsur.2019.04.108.

Peri V, Devlin P, Perry L, Richards T, Miles LF. Associations Between Nonanemic Iron Deficiency and Postoperative Outcomes in Cardiac Surgery: A Systematic Review and Meta-Analysis. Anesth Analg. 2024;139(1):47-57. doi: 10.1213/ANE.0000000000006822.

Tankard KA, Park B, Brovman EY, Bader AM, Urman RD. The Impact of Preoperative Intravenous Iron Therapy on Perioperative Outcomes in Cardiac Surgery: A Systematic Review. J Hematol. 2020;9(4):97-108. doi: 10.14740/jh696.

Kim HH, Park EH, Lee SH, Yoo KJ, Youn YN. Effect of Preoperative Administration of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency Anemia after Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Trial. J Clin Med. 2023;12(5):1737. doi: 10.3390/jcm12051737.

Johansson PI, Rasmussen AS, Thomsen LL. Intravenous iron isomaltoside 1000 (Monofer(R)) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: a randomized double-blind placebo-controlled clinical trial (the PROTECT trial). Vox Sang. 2015;109(3):257-66. doi: 10.1111/vox.12278.

Friedman T, Dann EJ, Bitton-Worms K, Makhoul M, Glam R, Weis A, et al. Intravenous iron administration before cardiac surgery reduces red blood cell transfusion in patients without anaemia. Br J Anaesth. 2023;131(6):981-8. doi: 10.1016/j.bja.2023.09.007.

Gupta S, Panchal P, Gilotra K, Wilfred AM, Hou W, Siegal D, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141-51. doi: 10.1093/icvts/ ivaa094.

Liu HM, Tang XS, Yu H, Yu H. The efficacy of intravenous iron for treatment of anemia before cardiac surgery: An updated systematic review and meta-analysis with trial sequential analysis. J Cardiothorac Surg. 2023;18(1):16. doi: 10.1186/s13019- 023-02119-2.

Manzini PM, Dall'Omo AM, D'Antico S, Valfre A, Pendry K, Wikman A, et al. Patient blood management knowledge and practice among clinicians from seven European university hospitals: a multicentre survey. Vox Sang. 2018;113(1):60-71. doi: 10.1111/ vox.12599.

Filipescu D, Stefan MG, Turconi SIB, Corneci D, Droc G, Goicea R, et al. Patient Blood Management in 2023: a Nationwide Survey of Anesthesiologists in Romania following the 2018 Guidelines. Blood Transfus. 2025;23(3):232-41. doi: 10.2450/ BloodTransfus.776.

Wilson MJ, Koopman-van Gemert A, Harlaar JJ, Jeekel J, Zwaginga JJ, Schipperus M. Patient blood management in colorectal cancer patients: a survey among Dutch gastroenterologists, surgeons, and anesthesiologists. Transfusion. 2018;58(10):2345-51. doi: 10.1111/trf.14807.

Bennett S, Ayoub A, Tran A, English S, Tinmouth A, McIsaac DI, et al. Current practices in perioperative blood management for patients undergoing liver resection: a survey of surgeons and anesthesiologists. Transfusion. 2018;58(3):781-7. doi: 10.1111/ trf.14465

Garcia-Zamora S, Lopez-Santi R, Sosa-Liprandi A, Hardy CA, Miranda-Arboleda AF, Echeverria LE, et al. Impact of an online course on enhancing the diagnosis of Chagas disease in Latin America. Arch Peru Cardiol Cir Cardiovasc. 2024;5(1):7-12. doi: 10.47487/apcyccv.v5i1.341.

Mignanelli G, Boyer R, Bonifas N, Rineau E, Moussali Y, Le Guen M. Survey of the Impact of Decision Support in Preoperative Management of Anemia (i-Anemia): Survey Study. JMIR Perioper Med. 2023;6:e49186. doi: 10.2196/49186.

Kloeser R, Buser A, Bolliger D. Treatment Strategies in Anemic Patients Before Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023;37(2):266-75. doi: 10.1053/j.jvca.2022.09.085.

Downloads

Published

2026-03-18

Issue

Section

Original articles

Most read articles by the same author(s)