Hypertonic saline solution and high dose of diuretic, ¿what do we know and how can we use them in persistent congestion?

Authors

  • Juan D. Orozco Burbano Departamento de Medicina Interna, Universidad del Cauca. Cauca, Colombia; Hospital Universitario San Jose. Popayan, Colombia. https://orcid.org/0000-0001-5449-3830
  • Clara I. Saldarriaga Giraldo Departamento de Cardiologia, Universidad Pontificia Bolivariana. Medellin, Colombia; Clinica CardioVID. Medellin, Colombia; Universidad de Antioquia. Medellin, Colombia. https://orcid.org/0000-0002-5945-1127
  • Diego A. Echeverri Marin Departamento de Cardiologia, Universidad Pontificia Bolivariana. Medellin, Colombia; Clinica CardioVID. Medellin, Colombia; Universidad de Antioquia. Medellin, Colombia. https://orcid.org/0000-0002-0551-5279

DOI:

https://doi.org/10.47487/apcyccv.v2i4.159

Keywords:

Heart failure, Saline solution, hypertonic, Furosemide

Abstract

The presence of decompensated heart failure continues to be a condition with high rates of hospitalization, impact on the health system, and quality of life for those who suffer it. The mainstay of treatment in these cases are diuretics. However, the resistance to this pharmacological group may occasionally occur, generating an inadequate negative fluid balance and persistence of congestion with negative clinical outcomes. Hypertonic saline solution with high doses of diuretic emerges as a therapeutic option for this group of patients with probable physiological, and clinical benefits on hospitalization and re-admission rates due to heart failure decompensation. A review of the most relevant aspects and benefits of this combination is discussed in this article.

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References

Joseph SM, Cedars AM, Ewald GA, Geltman EM, Mann DL. Acute decompensated heart failure: contemporary medical management. Texas Heart Inst J. 2009;36(6):510-20. Erratum in: Tex Heart Inst J. 2010;37(1):135.

Mangini S, Pires PV, Braga FG, Bacal F. Decompensated heart failure. Einstein (Sao Paulo). 2013 Jul-Sep;11(3):383-91. doi: 10.1590/s1679-45082013000300022.

Arrigo M, Jessup M, Mullens W, Reza N, Shah AM, Sliwa K, Mebazaa A. Acute heart failure. Nat Rev Dis Primers. 2020 Mar 5;6(1):16. doi: 10.1038/s41572-020-0151-7.

Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, et al. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report from the American Heart Association. Circulation. 2016 Jan 26;133(4):447-54. doi: 10.1161/CIR.0000000000000366.

Njoroge JN, Teerlink JR. Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure. Circ Res. 2021 May 14;128(10):1468-1486. doi: 10.1161/CIRCRESAHA.121.318186.

Scott MC, Winters ME. Congestive Heart Failure. Emerg Med Clin North Am. 2015 Aug;33(3):553-62. doi: 10.1016/j.emc.2015.04.006.

Shah N, Madanieh R, Alkan M, Dogar MU, Kosmas CE, Vittorio TJ. A perspective on diuretic resistance in chronic congestive heart failure. Ther Adv Cardiovasc Dis. 2017 Oct;11(10):271-278. doi: 10.1177/1753944717718717.

Bowman BN, Nawarskas JJ, Anderson JR. Treating Diuretic Resistance: An Overview. Cardiol Rev. 2016 Sep-Oct;24(5):256-60. doi: 10.1097/CRD.0000000000000116.

Griffin M, Soufer A, Goljo E, Colna M, Rao VS, Jeon S, et al. Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center’s Experience. JACC Heart Fail. 2020 Mar;8(3):199-208. doi: 10.1016/j.jchf.2019.10.012.

De Vecchis R, Esposito C, Ariano C, Cantatrione S. Hypertonic saline plus i.v. furosemide improve renal safety profile and clinical outcomes in acute decompensated heart failure: A meta-analysis of the literature. Herz. 2015 May;40(3):423-35. doi: 10.1007/s00059-013-4041-6.

Ter Maaten JM, Valente MA, Damman K, Hillege HL, Navis G, Voors AA. Diuretic response in acute heart failure-pathophysiology, evaluation, and therapy. Nat Rev Cardiol. 2015 Mar;12(3):184-92. doi: 10.1038/nrcardio.2014.215.

Valente MA, Voors AA, Damman K, Van Veldhuisen DJ, Massie BM, O’Connor CM, et al. Diuretic response in acute heart failure: clinical characteristics and prognostic significance. Eur Heart J. 2014 May 14;35(19):1284-93. doi: 10.1093/eurheartj/ehu065.

Covic A, Copur S, Tapoi L, Afsar B, Ureche C, Siriopol D, et al. Efficiency of Hypertonic Saline in the Management of Decompensated Heart Failure: A Systematic Review and Meta-Analysis of Clinical Studies. Am J Cardiovasc Drugs. 2021 May;21(3):331-347. doi: 10.1007/s40256-020-00453-7.

Tuttolomondo A, Pinto A, Parrinello G, Licata G. Intravenous highdose furosemide and hypertonic saline solutions for refractory heart failure and ascites. Semin Nephrol. 2011;31(6):513-522. doi: 10.1016/j.semnephrol.2011.09.006.

Casu G, Merella P. Diuretic Therapy in Heart Failure – Current Approaches. Eur Cardiol. 2015 Jul;10(1):42-47. doi: 10.15420/ecr.2015.10.01.42.

Costanzo MR. Hypertonic Saline: The Genesis of the Exodus of Fluid in Heart Failure? JACC Heart Fail. 2020 Mar;8(3):209-211. doi: 10.1016/j.jchf.2019.11.010.

Paterna S, Di Gaudio F, La Rocca V, Balistreri F, Greco M, Torres D, et al. Hypertonic Saline in Conjunction with High-Dose Furosemide Improves Dose-Response Curves in Worsening Refractory Congestive Heart Failure. Adv Ther. 2015 Oct;32(10):971-82. doi: 10.1007/s12325-015-0254-9.

Gupta R, Testani J, Collins S. Diuretic Resistance in Heart Failure. Curr Heart Fail Rep. 2019 Apr;16(2):57-66. doi: 10.1007/s11897-019-0424-1.

Liszkowski M, Nohria A. Rubbing salt into wounds: hypertonic saline to assist with volume removal in heart failure. Curr Heart Fail Rep. 2010 Sep;7(3):134-9. doi: 10.1007/s11897-010-0018-4.

Lafrenière G, Béliveau P, Bégin JY, Simonyan D, Côté S, Gaudreault V, et al. Effects of hypertonic saline solution on body weight and serum creatinine in patients with acute decompensated heart failure. World J Cardiol. 2017 Aug 26;9(8):685-692. doi: 10.4330/wjc. v9.i8.685.

Parrinello G, Paterna S, Di Pasquale P, Torres D, Mezzero M, Cardillo M, et al. Changes in estimating echocardiography pulmonary capillary wedge pressure after hypersaline plus furosemide versus furosemide alone in decompensated heart failure. J Card Fail. 2011 Apr;17(4):331-9. doi: 10.1016/j.cardfail.2010.11.003.

Issa VS, Andrade L, Ayub-Ferreira SM, Bacal F, de Bragança AC, Guimarães GV, et al. Hypertonic saline solution for prevention of renal dysfunction in patients with decompensated heart failure. Int J Cardiol. 2013 Jul 15;167(1):34-40. doi: 10.1016/j.ijcard.2011.11.087.

Parrinello G, Di Pasquale P, Torres D, Cardillo M, Schimmenti C, Lupo U, et al. Troponin I release after intravenous treatment with high furosemide doses plus hypertonic saline solution in decompensated heart failure trial (Tra-HSS-Fur). Am Heart J. 2012 Sep;164(3):351-7. doi: 10.1016/j.ahj.2012.05.025.

Tuttolomondo A, Maida C, Casuccio A, Di Raimondo D, Fonte R, Vassallo V, et al. Effects of intravenous furosemide plus small-volume hypertonic saline solutions on markers of heart failure. ESC Heart Failure: 2021;411; 1-12. doi: https://doi.org/10.1002/ehf2.13511.

De Vecchis R, Ciccarelli A, Ariano C, Pucciarelli A, Cioppa C, Giasi A, et al. Renoprotektiver Effekt kleiner Volumina hypertoner Kochsalzlösung bei Patienten mit chronischer Herzinsuffizienz und Ödembildung: Ergebnisse einer Fall-Kontroll-Studie [Renoprotective effect of small volumes of hypertonic saline solution in chronic heart failure patients with marked fluid retention: results of a casecontrol study]. Herz. 2011 Feb;36(1):12-7. German. doi: 10.1007/s00059-010-3394-3.

Issa VS, Bacal F, Mangini S, Dias Carneiro RM, Naves de Freitas Azevedo CH, Chizzola PR, et al. Hypertonic saline solution for renal failure prevention in patients with decompensated heart failure. Arq Bras Cardiol. 2007 Oct;89(4):251-5. English, Portuguese. doi: 10.1590/s0066-782x2007001600007.

Paterna S, Fasullo S, Parrinello G, Cannizzaro S, Basile I, Vitrano G, et al. Short-term effects of hypertonic saline solution in acute heart failure and long-term effects of a moderate sodium restriction in patients with compensated heart failure with New York Heart Association class III (Class C) (SMAC-HF Study). Am J Med Sci. 2011 Jul;342(1):27-37. doi: 10.1097/MAJ.0b013e31820f10ad.

Gatzoflias S, Hao S, Ferreri NR. Induction of renal tumor necrosis factor-α and other autacoids and the beneficial effects of hypertonic saline in acute decompensated heart failure. Am J Physiol Renal Physiol. 2021 Jun 1;320(6):F1159-F1164. doi: 10.1152/ajprenal.00686.2020.

Gandhi S, Mosleh W, Myers RB. Hypertonic saline with furosemide for the treatment of acute congestive heart failure: a systematic review and meta-analysis. Int J Cardiol. 2014 May 1;173(2):139-45. doi: 10.1016/j.ijcard.2014.03.020.

Zepeda P, Rain C, Sepúlveda P. What are the effects of hypertonic saline plus furosemide in acute heart failure? Medwave. 2015 Aug 27;15 Suppl 2: e6233. English, Spanish. doi: 10.5867/medwave.2015.6233.

Liu C, Peng Z, Gao X, Gajic O, Dong Y, Prokop LJ, et al. Simultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis. Crit Care Med. 2021 Nov 1;49(11):e1163-e1175. doi: 10.1097/CCM.0000000000005174.

Gómez Mesa JE, Saldarriaga C, Jurado AM, Mariño A, Rivera A, Herrera A, et al. Consenso colombiano de falla cardíaca avanzada: capítulo de Falla Cardíaca, Trasplante Cardíaco e Hipertensión Pulmonar de la Sociedad Colombiana de Cardiología y Cirugía Cardiovascular. 2019; 26:3-24. doi: 10.1016/j.rccar.2019.06.001.

Paterna S, Di Pasquale P, Parrinello G, Amato P, Cardinale A, Follone G, et al. Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. Eur J Heart Fail. 2000 Sep;2(3):305-13. doi: 10.1016/s1388-9842(00)00094-5.

Engelmeier RS, Le TT, Kamalay S, Utecht KN, Nikstad TP, Kaliebe JW, et al. Randomized trial of high dose furosemide-hypertonic saline in acute decompensated heart failure with advanced renal disease. J Am Coll Cardiol 2012; 59: E958. doi: 10.1016/S0735-1097(12)60959-0.

Licata G, Di Pasquale P, Parrinello G, Cardinale A, Scandurra A, Follone G, Argano C, Tuttolomondo A, Paterna S. Effects of highdose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: long-term effects. Am Heart J. 2003 Mar;145(3):459-66. doi: 10.1067/mhj.2003.166.

Di Pasquale P, Sarullo FM, Paterna S. Novel strategies: challenge loop diuretics and sodium management in heart failure--part II. Congest Heart Fail. 2007 May-Jun;13(3):170-6. doi: 10.1111/j.1527-5299.2007.06534.x.

Jao GT, Chiong JR. Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options. Clin Cardiol. 2010 Nov;33(11):666-71. doi: 10.1002/clc.20822.

Morisawa D, Hirotani S, Oboshi M, Sugahara M, Fukui M, Ando T, et al. Combination of hypertonic saline and low-dose furosemide is an effective treatment for refractory congestive heart failure with hyponatremia. J Cardiol Cases. 2014 Feb 11;9(5):179-182. doi: 10.1016/j.jccase.2013.12.014.

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Published

2021-12-27

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