Levosimendan and post-cardiotomy low cardiac output syndrome: indisputable evidence or mere statistical coincidence?

Authors

  • Wildor Samir Cubas Llalle Departamento de Cirugía de Tórax y Cardiovascular, Hospital Nacional Edgardo Rebagliati Martins
  • Jean Pierre Carrion-Arcela Departamento de Cardiología, Hospital Nacional Almanzor Aguinaga Asenjo, Chiclayo, Perú.
  • Luz Gabriela Rosadio-Portilla Departamento de Cirugía de Tórax y Cardiovascular, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú.
  • Luis Murillo-Pérez Departamento de Cardiología Clínica, Instituto Nacional Cardiovascular “Carlos Alberto Peschiera Carrillo”, Lima, Perú.
  • Christian Soplopuco-Palacios Servicio de Cardiología Peri-operatoria, Instituto Nacional Cardiovascular “Carlos Alberto Peschiera Carrillo”, Lima, Perú.
  • Fabrizio Quiroz-Sánchez Servicio de Cardiología Peri-operatoria, Instituto Nacional Cardiovascular “Carlos Alberto Peschiera Carrillo”, Lima, Perú.

DOI:

https://doi.org/10.47487/apcyccv.v2i1.115

Keywords:

Levosimendan, ventricular dysfunction, cardiac surgery

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References

Pérez Vela JL, Jiménez Rivera JJ, Alcalá Llorente MÁ, et al. Síndrome de bajo gasto cardiaco en el postoperatorio de cirugía cardiaca. Perfil, diferencias en evolución clínica y pronóstico. Estudio ESBAGA. Medicina Intensiva. 2018;42(3):159-67. DOI: 10.1016/j.medin.2017.05.009

Weber C, Esser M, Eghbalzadeh K. Levosimendan Reduces Mortality and Low Cardiac Output Syndrome in Cardiac Surgery. 2020;68(5):401-9. DOI: 10.1055/s-0039-3400496

Papp Z, Agostoni P, Alvarez J, et al. Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use. Card Fail Rev. 2020;6:e19-e. DOI:10.15420/cfr.2020.03

Guarracino F, Heringlake M, Cholley B, et al. Use of Levosimendan in Cardiac Surgery: An Update After the LEVO-CTS, CHEETAH, and LICORN Trials in the Light of Clinical Practice. Journal of cardiovascular pharmacology. 2018;71(1):1-9. DOI: 10.1097/FJC.0000000000000551

van Diepen S, Mehta RH, Leimberger JD, et al. Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery. The Journal of thoracic and cardiovascular surgery. 2020;159(6):2302-9.e6. DOI: 10.1016/j.jtcvs.2019.06.020

Chen Q-H, Zheng R-Q, Lin H, et al. Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a metaanalysis of randomized controlled trials. Critical Care. 2017;21(1):1-11. DOI: 10.1186/s13054-017-1848-1.

Qiang H, Luo X, Huo JH, Wang ZQ. Perioperative Use of Levosimendan Improves Clinical Outcomes in Patients After Cardiac Surgery: A Systematic Review and Meta-Analysis. Journal of cardiovascular pharmacology. 2018;72(1):11-8. DOI: 10.1097/fjc.0000000000000584

Jiménez-Rivera JJ, Álvarez-Castillo A, Ferrer-Rodríguez J, et al. Preconditioning with levosimendan reduces postoperative low cardiac output in moderate-severe systolic dysfunction patients who will undergo elective coronary artery bypass graft surgery: a cost-effective strategy. J Cardiothorac Surg. 2020;15(1):108-. DOI: 10.1186/s13019-020-01140-z

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Published

2021-03-06

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