Acute myocardial infarction without obstructive coronary disease secondary to toxic multinodular goiter thyrotoxicosis
DOI:
https://doi.org/10.47487/apcyccv.v1i4.90Keywords:
Chest pain, Myocardial infarction, Thyrotoxicosis, Myocardial ischemiaAbstract
Acute myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) represents a diagnostic challenge in clinical practice. Documentation of an ischemic substrate is necessary for its diagnostic approach, with a treatment that must be specific according to the identified etiology. A group of these patients presents ischemia secondary to an alteration in the oxygen supply/demand ratio. We present the case of a female adult patient, with severe hyperthyroidism and thyrotoxicosis, who develops an acute coronary syndrome, with elevated troponin T and normal coronary arteries on coronariography. Treatment was aimed at treating the triggering cause, initially pharmacologically and later surgically, with a total resolution of the condition, symptomatic improvement in the patient, and a decrease in cardiac biomarkers.
Downloads
References
Tamis-Holland J, Jneid H, Reynolds H, et al. Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association. Circulation. 2019;139(18):E891-E908. doi:10.1161/CIR.0000000000000670.
Barr P, Harrison W, Smyth D, et al. Myocardial Infarction Without Obstructive Coronary Artery Disease is Not a Benign Condition (ANZACS-QI 10). Hear Lung Circ. 2018;27(2):165-174. doi:10.1016/j.hlc.2017.02.023.
Pasupathy S, Air T, Dreyer R, et al. Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries. Circulation. 2015;131(10):861-870. doi:10.1161/CIRCULATIONAHA.114.011201.
Klein I, Ojamaa K. Thyroid Hormone and the Cardiovascular System. Epstein FH, ed. N Engl J Med. 2001;344(7):501-509. doi:10.1056/NEJM200102153440707.
Klein I, Ojamaa K. Thyrotoxicosis and the heart. Endocrinol Metab Clin North Am. 1998;27(1):51-62. doi:10.1016/S0889-8529(05)70297-8.
Martínez M, Lobo J, Anguiano P, et al. Infarto agudo de miocardio y tirotoxicosis. Presentación de un nuevo caso. Rev Española Cardiol.1999;52(11):1.019-1.021. doi:10.1016/S0300-8932(99)75029-3.
Thygesen K, Alpert J, Jaffe A, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. doi:10.1093/eurheartj/ehy462.
Mukherjee D. Myocardial Infarction With Nonobstructive Coronary Arteries: A Call for Individualized Treatment. J Am Heart Assoc.2019;8(14):1-3. doi:10.1161/JAHA.119.013361.
Ross D, Burch H, Cooper D, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-1421.doi:10.1089/thy.2016.0229.