Knowledge about warfarin treatment in patients with atrial fibrillation or mechanical prosthetic valves
DOI:
https://doi.org/10.47487/apcyccv.v3i4.256Keywords:
Knowledge, Atrial Fibrillation, Cardiac Valve Prostheses, Warfarin, AnticoagulationAbstract
Objective. To determine the degree of knowledge about warfarin treatment in patients with atrial fibrillation or with mechanical prosthetic valves. Materials and methods. Descriptive, observational, cross-sectional study. The OAK test was applied to all adult patients with a diagnosis of atrial fibrillation or with mechanical prosthetic valves treated with warfarin, who attended the hematology consultation from May 17 to November 10, 2022, at the “Instituto Nacional Cardiovascular Carlos Alberto Peschiera Carrillo”. Results. A total of 150 patients participated, 64% were male, with a mean age of 60.3 ± 15 years, 45.3% with a diagnosis of atrial fibrillation and 54.7% with mechanical prosthetic valves. The mean OAK test score was 44.4% (8.4/19), only 6% (n=9) achieved a satisfactory score ≥75.0%, the percentage of correct answers according to dimensions was: 68 % in forms of use, 39.3% in interactions and complications and 41.1% in INR control. A 40.7% did not understand the meaning of the term INR and 81.3% did not know their optimal values. Conclusions. The patient’s degree of knowledge about warfarin treatment was inadequate; both in its use, interactions and complications. Considering that it is a difficult drug to use, due to its narrow therapeutic window and its multiple interactions, inadequate knowledge of its use may contribute to inappropriate anticoagulation.
Downloads
References
Dünner D, Ramón Soto J. Tratamiento anticoagulante oral con énfasis en sus indicaciones en cardiología. Rev Méd Clín Las Condes. 2018;29(1):76-86. doi: 10.1016/j.rmclc.2018.02.007.
Ávila M, Papuzinski C, Ahumada S, Vidal C. Factores asociados a INR fuera de rango terapéutico en usuarios de terapia anticoagulante oral con antagonistas de vitamina K. Rev Chil Cardiol. 2014;33(1):33-7. doi:10.4067/S0718-85602014000100004.
Morillo CA, Banerjee A, Perel P, Wood D, Jouven X. Atrial fibrillation: the current epidemic. J Geriatr Cardiol JGC. 2017;14(3):195-203. doi: 10.11909/j.issn.1671-5411.2017.03.011.
Naser N, Dilic M, Durak A, Kulic M, Pepic E, Smajic E, et al. The Impact of Risk Factors and Comorbidities on The Incidence of Atrial Fibrillation. Mater Sociomed. 2017;29(4):231-6. doi: 10.5455/ msm.2017.29.231-236.
Prosthetic Heart Valves: Practice Essentials, Background, Design Features. Medscape [Internet]. 2022 [citado 5 de diciembre de 2022]. Disponible en: https://emedicine. medscape.com/article/780702-overview?icd=login_success_ gg_match_norm%20HYPERLINK%20%22https://emedicine. medscape.com/article/780702-overview?icd=login_ success_gg_match_norm&isSocialFTC=true%22&%20 HYPERLINK%20%22https://emedicine.medscape.com/ article/780702-overview?icd=login_success_gg_match_ norm&isSocialFTC=true%22isSocialFTC=true#a4
Marín A, Neira V, Aizman A, Paredes A, Palma S, Ruiz M, et al. Eficacia y seguridad del tratamiento anticoagulante oral con antagonistas de vitamina K en pacientes con prótesis valvulares cardíacas. Rev Chil Cardiol. 2014;33(1):27-32. doi: 10.4067/S0718-85602014000100003.
BrandtR,PibarotP.Prostheticheartvalves:Part1–Selection.e-Journal of Cardiology Practice [Internet]. 2021;20(1) [citado 21 de agosto de 2022]. Disponible en: https://www.escardio.org/Journals/E-Journal- of-Cardiology-Practice/Volume-20/prosthetic-heart-valves-part-1- selection, https://www.escardio.org/Journals/E-Journal-of-Cardiology- Practice/Volume-20/prosthetic-heart-valves-part-1-selection
Medina F. Epidemiología de la fibrilación auricular y el registro SAPHIR en Perú. Rev Peru Cardiol. 2012;38(2):64-8.
Pérez Vela JL, Perales y Rodríguez de Viguri N. Manejo de la anticoagulación en pacientes con prótesis valvulares. Controversias. Med Intensiva. 2003;27(4):232-9.
Ministerio de Salud del Perú. 1361-2018/MINSA. Documento técnico: petitorio nacional único de medicamentos esenciales para el sector salud [Internet]. Lima: MINSA; 2018 [citado 2 de agosto de 2022]. Disponible en: https://www.digemid.minsa.gob.pe/UpLoad/ UpLoaded/PDF/Normatividad/2018/RM_1361-2018.pdf
Hull R, Garcia D, Vazquez S, Biology of warfarin and modulators of INR control. UpToDate [Internet]. 2022 [citado 5 de diciembre de 2022]. Disponible en: https://www.uptodate.com/contents/biology- of-warfarin-and-modulators-of-inr-control
Castelhanos Rojas R, Ferrer Herrera IM, Segura Pujal LA, Ojeda Matías MR, Alfonso Hernández MC. Resistencia y sensibilidad a la warfarina. Rev Arch Méd Camagüey. 2014;18(2):226-39.
De Caterina R, Husted S, Wallentin L, Andreotti F, Arnesen H, Bachmann F, et al. Vitamin K antagonists in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease. Thromb Haemost. 2013;110(6):1087-107. doi: 10.1160/ TH13-06-0443.
Lara A. Atención de enfermería al paciente anticoagulado desde atención primaria. Ocronos [Internet]. 2019 [citado 4 de octubre de 2022]. Disponible en: https://revistamedica.com/atencion-de- enfermeria-paciente-anticoagulado-atencion-primaria/
Marcatto LR, Sacilotto L, Tavares LC, Facin M, Olivetti N, Strunz CMC, et al. Pharmaceutical Care Increases Time in Therapeutic Range of Patients With Poor Quality of Anticoagulation With Warfarin. Front Pharmacol. 2018;9:1052. doi: 10.3389/fphar.2018.01052.
SmithMB,ChristensenN,WangS,StroheckerJ,DayJD,WeissJP,etal. Warfarin knowledge in patients with atrial fibrillation: implications for safety, efficacy, and education strategies. Cardiology. 2010;116(1):61- 9. doi: 10.1159/000314936.
Fariborz Farsad B, Dastan F, Salamzadeh J, Moghadamnia Z, Eskandari R, Fahimi F. Assessment of Outpatients’ Knowledge and Adherence on Warfarin: The Impact of a Simple Educational Pamphlet. Iran J Pharm Res IJPR. 2019;18(Suppl1):315-20. doi: 10.22037/ ijpr.2020.14766.12641.
Shrestha S, Sapkota B, Kumpakha A, Acharya U, Sharma R. Evaluation of patients’ knowledge on warfarin in outpatient pharmacy of a tertiary care cardiac center. BMC Res Notes. 2015;8:429. doi: 10.1186/ s13104-015-1416-1.
Shuaib W, Iftikhar H, Alweis R, Shahid H. Warfarin Therapy: Survey of Patients’ Knowledge of their Drug Regimen. Malays J Med Sci MJMS. 2014;21(4):37-41.
Zeolla MM, Brodeur MR, Dominelli A, Haines ST, Allie ND. Development and validation of an instrument to determine patient knowledge: the oral anticoagulation knowledge test. Ann Pharmacother. 2006;40(4):633-8. doi: 10.1345/aph.1G562.
Araujo J. Conocimientos acerca del tratamiento anticoagulante oral en un grupo de pacientes: estudio transversal - Ridec. Revista Iberoamericana de Enfermería Comunitaria (RIdEC). 2018;11(1):6-20.
da Silva M, Nogueira M, Dias D, Soriano M, Martins S, Parreiras M. Adaptação Transcultural do Oral Anticoagulation Knowledge Test para o Português do Brasil. Ciênc Amp Saúde Coletiva. 2017;22(5):1615-29. doi: 10.1590/1413-81232017225.17782015.
Lam ASM, Lee IMH, Mak SKS, Yan BPY, Lee VWY. Warfarin control in Hong Kong clinical practice: a single-centre observational study. Hong Kong Med J Xianggang Yi Xue Za Zhi. 2020;26(4):294-303. doi: 10.12809/hkmj208416.
Rahmani P, Guzman C, Kezouh A, Blostein M, Kahn SR. Association Between Patient Knowledge of Anticoagulation, INR Control, and Warfarin-Related Adverse Events. J Pharm Technol JPT Off Publ Assoc Pharm Tech. 2016;32(4):150-9. doi: 10.1177/8755122516644622.
Falcón Romero M, García Gambín Y, Fernández López L, Luna Ruiz Cabello A, Navarro Zaragoza J. Conocimientos sobre el tratamiento y baja adhesión terapéutica de los pacientes anticoagulados. Salud(i) Ciencia. 2017;22(4):324-30. doi: 10.21840/siic/153104.
United Nations. World Population Prospects 2019: Highlights. Multimedia Library [Internet]. California: United Nations; 2019 [citado 1 de junio de 2022]. Disponible en: https://www.un.org/ development/desa/publications/world-population-prospects-2019- highlights.html
Shikdar S, Vashisht R, Bhattacharya PT. International Normalized Ratio (INR). En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [citado el 28 de noviembre de 2022]. Disponible en: http://www.ncbi.nlm.nih.gov/books/NBK507707/
Yabeyu AB, Ayanaw MA, Haile KT, Kifle ZD. Evaluation of patients’ knowledge of warfarin at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Metab Open. 2021;13:100155. doi: 10.1016/j. metop.2021.100155.
Gilbert A. I’ve missed a dose; what should I do? Aust Prescr. 2002;25:16-8. doi: 10.18773/austprescr.2002.010.
Sheringham Medical Practice: Anticoagulation Safety Information [Internet]. Londres: NHS; 2022 [citado el 27 de noviembre de 2022]. Disponible en: https://www.sheringhammedical.nhs.uk/practice- information/anticoagulation-safety-information/
Park JN, Lee JS, Noh MY, Sung MK. Association Between Usual Vitamin K Intake and Anticoagulation in Patients Under Warfarin Therapy. Clin Nutr Res. 2015;4(4):235-41. doi: 10.7762/cnr.2015.4.4.235.
Violi F, Lip GY, Pignatelli P, Pastori D. Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True?: A Systematic Review. Medicine (Baltimore). 2016;95(10):e2895. doi: 10.1097/MD.0000000000002895.
Use of INR for monitoring warfarin treatment [Internet]. Dunedin: BPAC NZ; 2010 [citado el 11 de julio de 2022]. Disponible en: https:// bpac.org.nz/bt/2010/november/inr.aspx
Baysal E, Midilli TS. Effects of structured patient education on knowledge level and INR control of patients receiving warfarin: Randomized Controlled Trial. Pak J Med Sci. 2018;34(2):240-6. doi: 10.12669/pjms.342.14216.
Tideman PA, Tirimacco R, St John A, Roberts GW. How to manage warfarin therapy. Aust Prescr. 2015;38(2):44-8. doi: 10.18773/ austprescr.2015.016.
Barnes GD, Kong X, Cole D, Haymart B, Kline-Rogers E, Almany S, et al. Extended International Normalized Ratio testing intervals for warfarin-treated patients. J Thromb Haemost JTH. 2018;16(7):1307- 12. doi: 10.1111/jth.14150.
Published
Issue
Section
License
Copyright (c) 2022 The journal is headline of the first publication, then the author giving credit to the first publication.
This work is licensed under a Creative Commons Attribution 4.0 International License.