An unusual case of Candida parapsilosis endocarditis of the native tricuspid valve secondary to a tunneled dialysis catheter



Palabras clave:

Endocarditis, Candida parapsilosis, Catheter-Related Infections


Candida endocarditis is a severe disease associated with high mortality rates. Candida parapsilosis is frequently identified as the causative pathogen in intravenous drug users and is commonly associated with nosocomial infections, primarily due to its ability to form biofilms on catheters or other foreign bodies. Here, we present a rare case of Candida parapsilosis endocarditis affecting the native tricuspid valve in a 35-year-old male patient with end-stage chronic kidney disease (Stage V), who had a suspected fungal infection related to the left cervical catheter. The patient received treatment with caspofungin and underwent excision of a verrucous tumor on the tricuspid valve. Despite encountering postoperative complications, the patient was discharged on fluconazole treatment and scheduled for follow-up. Candida endocarditis poses a clinical challenge that necessitates a multidisciplinary approach and tailored management due to its infrequent occurrence and higher mortality rate compared to bacterial endocarditis.


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Kamde SP, Anjankar A. Pathogenesis, diagnosis, antimicrobial therapy, and management of infective endocarditis, and its complications. Cureus. 2022;14(9):e29182. doi: 10.7759/ cureus.29182.

Chu MD, MHS V. Native valve endocarditis: Epidemiology, risk factors, and microbiology [Internet]. [cited 2023 Apr 8]. Available from: native-valve-endocarditis-epidemiology-risk-factors-and- microbiology?search=endocarditis%20etiology&source=search_ result&selectedTitle=1~150&usage_ type=default&display_rank=1.

Kauffman CA. Candida endocarditis and suppurative thrombophlebitis [Internet]. [cited 2023 Apr 8]. Available from: and-suppurative-thrombophlebitis?search= endocarditis%20 etiology&topicRef=2151&source=see_link.

Garzoni C, Nobre VA, Garbino J. Candida parapsilosis endocarditis: a comparative review of the literature. Eur J Clin Microbiol Infect Dis. 2007;26(12):915-26. doi: 10.1007/s10096-007-0386-1.

Mamtani S, Aljanabi NM, Gupta Rauniyar RP, Acharya A, Malik BH. Candida endocarditis: A review of the pathogenesis, morphology, risk factors, and management of an emerging and serious condition. Cureus. 2020;12(1):e6695. doi: 10.7759/cureus.6695.

Giuliano S, Guastalegname M, Russo A, Falcone M, Ravasio V, Rizzi M, et al. Candida endocarditis: systematic literature review from 1997 to 2014 and analysis of 29 cases from the Italian Study of Endocarditis. Expert Rev Anti Infect Ther. 2017;15(9):807-18. doi: 10.1080/14787210.2017.1372749.

Yamin DH, Husin A, Harun A. Risk factors of candida parapsilosis catheter-related bloodstream infection. Front Public Health. 2021;9:631865. doi: 10.3389/fpubh.2021.631865.

Chambers HF, Bayer AS. Native-valve infective endocarditis. N Engl J Med. 2020;383(6):567-76. doi: 10.1056/NEJMcp2000400.

Teixeira da Silva F, Cardoso FS, Esteves A, Carvalho J, Maia R. Relapsing Candida parapsilosis endocarditis with septic embolization: A case report. Cureus. 2021;13(2):e13159. doi: 10.7759/cureus.13159.

BritoMonteiroM,SismeiroR,NegrãoC,JonetM,SimoaG.Fungal endocarditis: A case report. Cureus. 2021;13(12):e20156. doi: 10.7759/cureus.20156.

PappasPG,KauffmanCA,AndesDR,ClancyCJ,MarrKA,Ostrosky- Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;62(4):e1-50. doi: 10.1093/cid/civ933.

Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, Rybak MJ, et al. Infective endocarditis in adults: Diagnosis, antimicrobial therapy, and management of complications: A scientific statement for healthcare professionals from the American Heart Association: A scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435-86. doi: 10.1161/ CIR.0000000000000296.

Delgado V, Ajmone Marsan N, De Waha S, Bonaros N, Brida M, Burri H, et al. 2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM). Eur. Heart J. 2023:1-95. doi: 10.1093/eurheartj/ehad193.




Cómo citar

Zacarías Mendoza NV, Zevallos Goyzueta AV, Wu Chen A, Robles Velarde VJ. An unusual case of Candida parapsilosis endocarditis of the native tricuspid valve secondary to a tunneled dialysis catheter. Arch Peru Cardiol Cir Cardiovasc [nternet]. 30 de septiembre de 2023 [citado 9 de diciembre de 2023];4(3):118-21. isponible en:



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